Efficacy and Safety of Clopidogrel for Primary Prevention in Patients With Subclinical Coronary Atherosclerosis Identified on Imaging
Status: Recruiting
Location: See all (61) locations...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
The investigators will evaluate the efficacy and safety of clopidogrel for primary prevention in patients diagnosed with coronary atherosclerosis on imaging that did not require revascularization therapy. The trial will test the hypothesis that clopidogrel is beneficial in preventing major adverse cardiovascular and cerebrovascular events (MACCE) in patients with subclinical coronary atherosclerosis identified on imaging.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Healthy Volunteers: f
View:
• Male or female aged ≥40 years
• Patients with subclinical coronary atherosclerosis identified from coronary CT angiography or coronary angiography within 2 years without clinical events after an imaging study
• Without significant coronary artery stenosis (Diameter stenosis \>50%), which needs revascularization
• Agreement to give written informed consent
Locations
Other Locations
Republic of Korea
Andong Hospital
RECRUITING
Andong
Dong-A University Hospital
RECRUITING
Busan
Inje University Busan Paik Hospital
RECRUITING
Busan
Kosin University Gospel Hospital
RECRUITING
Busan
Pusan National University Hospital
RECRUITING
Busan
Gyeongsang National University Changwon Hospital
RECRUITING
Changwon
Soonchunhyang University Cheonan Hospital
RECRUITING
Cheonan
Soonchunhyang University Cheonan Hospital
RECRUITING
Cheonan
Soonchunhyang University Cheonan Hospital
RECRUITING
Cheonan
Chungbuk National University Hospital
RECRUITING
Cheongju-si
Hallym University Chuncheon Sacred Heart Hospital
RECRUITING
Chuncheon
Kangwon National University Hospital
RECRUITING
Chuncheon
Kangwon National University Hospital
RECRUITING
Chuncheon
Keimyung University Dongsan Hospital
RECRUITING
Daegu
Yeungnam University Medical Center
RECRUITING
Daegu
Chungnam National University Hospital
RECRUITING
Daejeon
Eulji University Hospital, Daejeon
RECRUITING
Daejeon
Gangneung Asan Hospital
RECRUITING
Gangneung
Chonnam National University Hospital
RECRUITING
Gwangju
Chonnam National University Hospital
RECRUITING
Gwangju
Kwangju Christian Hospital
RECRUITING
Gwangju
Chung-Ang University Gwangmyeong Hospital
RECRUITING
Gyeonggi-do
Eulji University Hospital, Uijeongbu
RECRUITING
Gyeonggi-do
Hallym University Dongtan Sacred Heart Hospital
RECRUITING
Gyeonggi-do
Hallym University Sacred Heart Hospital
RECRUITING
Gyeonggi-do
Inje University Ilsan Paik Hospital
RECRUITING
Gyeonggi-do
Myongji Hospital
RECRUITING
Gyeonggi-do
National Health Insurance Service Ilsan Hospital
RECRUITING
Gyeonggi-do
Sejong General Hospital, Bucheon
RECRUITING
Gyeonggi-do
Soonchunhyang University Bucheon Hospital
RECRUITING
Gyeonggi-do
Yonsei University Yongin Severance Hospital
RECRUITING
Gyeonggi-do
Chonnam National University Hwasun Hospital
RECRUITING
Hwasun
Catholic Kwandong University International St. Mary's Hospital
RECRUITING
Incheon
Gachon University Gil Medical Center
RECRUITING
Incheon
Jeju National University Hospital
RECRUITING
Jeju City
Jesus Hospital, Jeonju
RECRUITING
Jeonju
Gyeongsang National University Hospital
RECRUITING
Jinju
Pohang Stroke And Spine Hospital
RECRUITING
Pohang
Chungnam National University Sejong Hospital
RECRUITING
Sejong
Chung-Ang University Hospital
RECRUITING
Seoul
Chung-Ang University Hospital
RECRUITING
Seoul
Ewha Womans University Seoul Hospital
RECRUITING
Seoul
Ewha Womans University Seoul Hospital
RECRUITING
Seoul
Hallym University Kangdong Sacred Heart Hospital
RECRUITING
Seoul
Hallym University Kangdong Sacred Heart Hospital
RECRUITING
Seoul
Hallym University Kangnam Sacred Heart Hospital
RECRUITING
Seoul
Hanyang University Hospital
RECRUITING
Seoul
Inje University Sanggye Paik Hospital
RECRUITING
Seoul
Kangbuk Samsung Hospital
RECRUITING
Seoul
Korea University Anam Hospital
RECRUITING
Seoul
Korea University Guro Hospital
RECRUITING
Seoul
Kyung Hee University Hospital
RECRUITING
Seoul
Samsung Medical Center
RECRUITING
Seoul
Seoul Medical Center
RECRUITING
Seoul
Seoul Metropolitan Government - Seoul National University Boramae Medical Center
RECRUITING
Seoul
Seoul National University Hospital
RECRUITING
Seoul
Soonchunhyang University Seoul Hospital
RECRUITING
Seoul
Veterans Health Service Medical Center
RECRUITING
Seoul
Yonsei University Gangnam Severance Hospital
RECRUITING
Seoul
Ulsan University Hospital
RECRUITING
Ulsan
Yonsei University Wonju Severance Christian Hospital
RECRUITING
Wŏnju
Contact Information
Primary
Jung-Kyu Han, MD, PhD
hpcrates@gmail.com
821026765736
Time Frame
Start Date: 2023-03-22
Estimated Completion Date: 2031-12-31
Participants
Target number of participants: 11086
Treatments
Experimental: Clopidogrel treatment group
Patients assigned to the clopidogrel treatment group will maintain clopidogrel 75mg once a day for at least 5 years.
Active_comparator: No antiplatelet or anticoagulant group
Patients assigned to the no antiplatelet or anticoagulant group will not prescribe antithrombotics for at least 5 years. However, when there is a medical need for antithrombotic therapy during the follow-up, the prescription of antithrombotics is permitted with reporting to the research board.
Related Therapeutic Areas
Sponsors
Collaborators: Dong-A ST Co., Ltd., Samjin Pharmaceutical Co., Ltd., IlDong Pharmaceutical Co Ltd, CKD Pharmaceutical Limited, Yuhan Pharmaceutical Company, Hanmi Pharmaceutical co., ltd., Daewoong Pharmaceutical Co. LTD.
Leads: Seoul National University Hospital