In Vivo Atherosclerotic Plaque Calcium Characterization for Predicting Ruptured Plaques

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Recently, ultrashort echo time (UTE) MR, which allows detection of the ultrashort T2 components, has been used to image plaque calcification in ex vivo carotid and coronary arteries. The results demonstrated that UTE images are able to identify plaque calcification and enables accurate quantification of calcium volumes. However, gadolinium-based contrast agents during in vivo CMR could not be performed in these ex vivo study. Agnese et al. believed that calcifications with 18F-NaF PET uptake might be considered to represent dormant areas where on-going mineralization, which is a key sign to identify and localise ruptured and high risk coronary plaque. We, therefore, hypothesize that enhanced carotid calcification presented by UTE MR may be a critical sign for symptomatic patients. In this study, we will investigate the feasibility of enhanced UTE MR in human carotid arteries in vivo. Furthermore, we analyzed the correlation between UTE MR and microcalcification of in the carotid plaques. Based on the diagnostic ability of enhanced UTE MR for microcalcification, we will investigate the potential of enhanced calcification to distinguish symptomatic from asymptomatic patients with carotid atherosclerosis and research the prognostic ability of enhance calcufication in UTE MR.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: t
View:

• Patients referred for carotid endarterectomy or stent were prospectively enrolled.

Locations
Other Locations
China
Min Li
RECRUITING
Jinan
Contact Information
Primary
Zhen Yang, M.D.
taianyangzhen@126.com
18615658796
Time Frame
Start Date: 2019-06-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 60
Treatments
Asymptomatic group
Group with asymptomatic patients with carotid atherosclerosis.
Symptomatic group
Group with symptomatic patients with carotid atherosclerosis.
Related Therapeutic Areas
Sponsors
Leads: Li Min

This content was sourced from clinicaltrials.gov