Canadian Atopic Dermatitis Cohort for Translational Immunology and Imaging (CACTI) With a Nested BROadband vs Narrowband photoTherapy for Eczema (BRONTE) Randomized Controlled Trial

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Atopic dermatitis (eczema) is a complicated skin condition. In fact, it represents many different underlying problems. These include abnormalities in the skin barrier, the immune system and the ability to handle different bacteria. Despite many recent gains in the understanding of eczema, a lot needs to be learned. There is little evidence to select between some of the older treatments that are available now. Even the newest targeted therapy does not clear most patients' skin. In order to improve the understanding of eczema, how to treat it now, and to enable discovery of new treatments, the investigators plan to enroll patients into a large study at three centres in Canada (University of Toronto, McGill University and University of British Columbia). The study is called the Canadian Atopic Dermatitis Cohort for Translational Immunology and Imaging (CACTI). In this study, the investigators will collect data on how severe participants' eczema is and what treatments they use. For participants who give permission, the investigators will collect blood and skin biopsy samples to study the mechanisms underlying their disease. The investigators will test to see which form of phototherapy (Broadband or Narrowband Ultraviolet B phototherapy) works best for eczema in a randomized clinical trial. The investigators will also use advanced imaging techniques to visualize the skin. This trial registry entry, including the description of the treatment arms and outcomes, refer to the nested BROadband vs Narrowband photoTherapy for Eczema clinical trial.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Atopic dermatitis according to the Hanifin and Rajka criteria.

• Validated Investigator Global Assessment score of 3 or 4 out of 4

• Eczema Area and Severity Index (EASI) score ≥7.1

• Moderate to severe disease as above despite an adequate trial of topical therapy.

Locations
Other Locations
Canada
Women's College Hospital
RECRUITING
Toronto
Contact Information
Primary
Karen Lau
karen.lau@wchospital.ca
416-323-6400
Time Frame
Start Date: 2021-09-27
Estimated Completion Date: 2026-06
Participants
Target number of participants: 120
Treatments
Active_comparator: Narrowband UVB
Narrowband UVB phototherapy (full body) administered three times weekly according to individual clinical protocols.
Active_comparator: Broadband UVB
Broadband UVB phototherapy (full body) administered three times weekly according to individual clinical protocols.
Related Therapeutic Areas
Sponsors
Collaborators: McGill University Health Centre/Research Institute of the McGill University Health Centre, University of British Columbia, University of Toronto
Leads: Women's College Hospital

This content was sourced from clinicaltrials.gov