Biodiversity Interventions for Well-being - the Effect of Biodiversity Exposure on Atopic Dermatitis
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other, Biological
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The prevalence of atopic dermatitis has increased along with urbanization and biodiversity loss. According to biodiversity hypothesis, the main reason is urban lifestyle and reduced contact to microbial diversity. Previous studies indicate association between atopic dermatitis and exposure to natural microbes in childhood. Sand Play - the Effect of Biodiversity Exposure on Atopic Dermatitis will investigate whether the exposure to microbial diversity in sandbox reduces the symptoms of atopic dermatitis, alters commensal microbiota and modifies immune regulation in children.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 2
Maximum Age: 5
Healthy Volunteers: t
View:
• Eczema Area and Severity Index ≥ 2
Locations
Other Locations
Finland
Natural Resources Institute Finland
RECRUITING
Helsinki
Tampere University
RECRUITING
Tampere
Contact Information
Primary
Sanna Hurtola
sanna.hurtola@luke.fi
+358295322500
Time Frame
Start Date: 2023-05-26
Estimated Completion Date: 2027-09-30
Participants
Target number of participants: 80
Treatments
Experimental: Microbial intervention
Children receive an indoor sandbox and cultivation set including soil- and plant-based material with high microbial diversity.
Placebo_comparator: placebo
Children receive an indoor sandbox and cultivation set including placebo material with low microbial diversity.
Related Therapeutic Areas
Sponsors
Leads: Natural Resources Institute Finland
Collaborators: Tampere University