• Have a diagnosis of AD that has been present for \>=1 year prior to the Screening visit

• Moderate-to-severe AD at Screening and Baseline visits

• History of inadequate response to treatment with topical medications, or medical determination that topical therapies are inadvisable

• Applied a stable dose of non-medicated over-the-counter emollient/moisturizer of their choice on their skin for \>=14 days prior to Baseline visit and agrees to continue using the same moisturizer throughout the study except the day of the study visits.

• Have completed itch questionnaires in the electronic diary for \>=4 of 7 days prior to Baseline visit