• Age between 18 and 65 years;

• Male or female;

• The diagnosis of atopic dermatitis (AD) is defined according to the criteria of UK Working Party with at least 3 of the following 5 criteria are present; history of flexural involvement, history of a dry skin, onset under the age of 2, personal history of asthma or allergic rhinitis, history of a pruritic skin condition, and visible flexural dermatitis.

• Generalized AD defined by AD involved ≥50% of total body surface area with head and neck involvement. Or HNAD defined by AD involving at least 80% of the head and neck area with or without AD involvement outside the head and neck area but \<20% of total body surface area.

• With topical anti-inflammatory treatments for AD (including; topical steroids and/or topical tacrolimus)

• Free, informed and written consent, signed by the patient and the investigator before any examination required by the trial;

• Affiliation to social security scheme (beneficiary or assignee)

• Healthy control are the same age and sex.