The Role of the Interleukin-13 Pathways on Pain and Itch Sensitivity in Patients With Atopic Dermatitis and Healthy Volunteers

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Atopic dermatitis (AD) is as chronic, inflammatory skin disorder affecting 20% of the world's population. Intense itch and skin pain are the main symptoms. Research has shown that the proteins interleukins are involved in inflammation and itch in atopic dermatitis. The medicinal product called Lebrikizumab, used for treatment of AD, has shown to block the interleukin called IL-13. The purpose of this experiment is to evaluate the role of IL-13 in itch in both healthy subjects and people with atopic dermatitis.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:

• Healthy men and women

• 18-60 years

Locations
Other Locations
Denmark
Aalborg University
NOT_YET_RECRUITING
Aalborg
Aalborg University
RECRUITING
Gistrup
CNAP
ACTIVE_NOT_RECRUITING
Gistrup
Contact Information
Primary
Silvia Lo Vecchio
slv@hst.aau.dk
21397785
Time Frame
Start Date: 2025-01-06
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 20
Treatments
Experimental: Lebrikizumab
The initial doses will be subcutaneous Lebrikizumab 500 mg (two 250 mg injections) at both week 0 (baseline) and week 2, followed by 250 mg administered subcutaneously at week 4.
Related Therapeutic Areas
Sponsors
Leads: Aalborg University

This content was sourced from clinicaltrials.gov