• Patients with a diagnosis of AD for at least 1 year according to the American Academy of Dermatology's consensus criteria prior to the screening visit meeting all of the following criteria:

• EASI≥16 at Screening and Baseline visits;

• Investigator's Global Assessment (IGA) score of≥3 at Screening and Baseline visits;

⁃ 10% Body Surface Area (BSA) of AD involvement at Screening and Baseline visits;

• Mean of weekly Pruritus Numeric Rating Scale (NRS) severity score≥4 at Baseline;