Sodium in the Skin and Atopic Dermatitis
Status: Recruiting
Location: See all (2) locations...
Study Type: Observational
SUMMARY
The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above. The study is designed to test whether diet and skin barrier function are associated with skin sodium concentration and whether skin sodium concentration is linked to atopic dermatitis and immune profiles over time. Participants will be asked to complete questionnaires, provide bio samples, and undergo non-contrast sodium MRI at 2-3 time points over 3-24 months.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Healthy Volunteers: t
View:
• Ages 50 years and above
• Willing to undergo non-contrast MRI (e.g., no contraindications to MRI, such as cardiac pacemakers, non-compatible intracranial vascular clips or pregnancy).
Locations
United States
California
San Francisco VA Medical Center
RECRUITING
San Francisco
UCSF Mt Zion Campus
RECRUITING
San Francisco
Contact Information
Primary
Jie Zhu, MD
Jie.Zhu2@ucsf.edu
415-502-0433
Backup
Katrina Abuabara, MD
katrina.abuabara@ucsf.edu
415-514-9769
Time Frame
Start Date: 2025-05-12
Estimated Completion Date: 2028-08-30
Participants
Target number of participants: 90
Treatments
No History of AD
Healthy controls
Mild AD
Eczema Area Severity Index (EASI): scores \<7 will be considered mild AD
Severe AD
Eczema Area Severity Index (EASI): scores \>21 will be considered severe
Related Therapeutic Areas
Sponsors
Leads: University of California, San Francisco
Collaborators: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)