Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury
The purpose of this study is to stimulate the circuits in the spinal cord that are directly responsible for hemodynamic control to restore hemodynamic stability in patients with chronic cervical or high-thoracic spinal cord injury. The ultimate objective of this feasibility study is to provide preliminary safety and efficacy measures on the ability of the hemodynamic Targeted Epidural Spinal Stimulation (TESS) to ensure the long-term management of hemodynamic instability and reduce the incidence and severity of orthostatic hypotension and autonomic dysreflexia episodes in humans with chronic cervical or high-thoracic spinal cord injury. In addition, the long-term safety and efficacy of TESS on cardiovascular health, respiratory function, spasticity, trunk stability and quality of life in patients with chronic spinal cord injury will be evaluated.
• Age 18 to 70 years old
• Able to undergo the informed consent/assent process
• Radiologically confirmed spinal cord injury
• Spinal cord injury between C3 and T6
• Classified with AIS A or B Spinal cord injury
• Stable medical, physical and psychological condition as considered by Investigators
• Greater than 1 year since initial injury and at least 6 months from any required spinal instrumentation
• Confirmed orthostatic hypotension and autonomic dysreflexia
• Willing to attend all scheduled appointments