Repeated Sampling of the Oral Microbiome to Improve Detection of Barrett's Esophagus
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE). Potential participants will be identified through chart review of patients who have had an endoscopy in the past three years.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Scheduled for an upper endoscopy or had upper endoscopy within past three years
• Eighteen years of age or older
• Capable of producing a saliva sample
• Able to give informed consent
• For BE patients only: Endoscopic evidence of Barrett's esophagus (at least 1 cm maximal BE length; i.e. Prague classification: any C, M≥1), and intestinal metaplasia present on esophageal biopsies
Locations
United States
Michigan
University of Michigan
RECRUITING
Ann Arbor
New York
Columbia University Irving Medical Center
RECRUITING
New York
Contact Information
Primary
Julian Abrams, MD
ja660@cumc.columbia.edu
212-305-1909
Backup
Katharine Boyce, RN
kb3217@cumc.columbia.edu
Time Frame
Start Date: 2021-03-19
Estimated Completion Date: 2026-08
Participants
Target number of participants: 275
Treatments
Control
Patients who have undergone an endoscopy within the last three years and have never been diagnosed with Barrett's esophagus.
Barrett's Esophagus
Patients who have undergone an endoscopy within the last three years and have histologically confirmed Barrett's esophagus. BE segment must be M\>1cm, and has not be treated with endoscopic eradication therapy (focal mucosal resection without subsequent eradication therapy is allowed).
Related Therapeutic Areas
Sponsors
Leads: Columbia University
Collaborators: University of Michigan, National Cancer Institute (NCI)