Defining Outcome Measures for Behavioural and Emotional Problems in Dystrophinopathies
Study aims to develop and to evaluate the neurophysiological and physiological response to a classical conditioning task.To better understand how Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD) impacts mental health and how to assess it. Participants invited to complete questionnaires about behaviour, cognitive function and social interactions, complete computer tasks and have an optional MRI brain scan,
• DMD patients:
∙ Male
‣ Age range 7-17 years
‣ A genetically proven diagnosis of DMD.
‣ A genetic mutation that abrogates expression of Dp427 alone (assigned in DMD Group 1: Dp427-/Dp140+) or both Dp427 and Dp140 (assigned to DMD Group 2: Dp427-/Dp140-).
‣ Ability to consent/assent
• BMD patients:
⁃ Male
⁃ Age range 7-17 years
⁃ A genetically proven diagnosis of BMD.
⁃ A genetic mutation that decreases expression of Dp427 alone (assigned to BMD Group 1), of both Dp427 and Dp140 (assigned to BMD Group 2).
⁃ Ability to consent/assent
• Control participants:
⁃ Male
⁃ Age range 7-17 years.
⁃ Ability to consent/assent