Establishment and Validation of a Standardized Definition for Biliary Atresia Associated Cholangitis After Hepatic Portoenterostomy

Status: Unknown
Location: See location...
Intervention Type: Drug
Study Type: Observational
SUMMARY

Cholangitis is the most common postoperative complication of biliary atresia, with a reported incidence of 40-90%, which seriously affects the surgical effect, survival rate and the quality of life and prognosis of patients. Without of direct evidence, the diagnosis of cholangitis sometimes is difficult to make, thus most of them are diagnosed based on the symptoms of children. According to literature reports, different centers and regions have different diagnostic criteria for postoperative cholangitis after hepatic portoenterostomy, which has a great influence on the accuracy of the incidence rate and appropriate treatment of cholangitis, and also brings differences in the analysis of the causes and prognostic factors of cholangitis. Based on the above reasons, we used the Delphi method,in which worldwidely 48 experts participated in, to establish the diagnostic scoring system for postoperative cholangitis after biliary atresia. Now we aimed to verify the specificity and sensitivity of the new scoring system through clinical cases, in order to unify and standardize the diagnostic criteria and provide help for the diagnosis and treatment of cholangitis after biliary atresia.

Eligibility
Participation Requirements
Sex: All
Maximum Age: 16
Healthy Volunteers: f
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• ① Admission time: 2019.01.01-2021.12.31;

• ② The first diagnosis after discharge was cholangitis

Locations
Other Locations
China
NJMU
RECRUITING
Nanjing
Contact Information
Primary
Xie Hua, Dr
xiehua3955@126.com
+8613611573952
Backup
Lu changgui, Dr
+8613611573952
Time Frame
Start Date: 2022-07-15
Completion Date: 2022-12-31
Participants
Target number of participants: 500
Treatments
Postoperative cholangitis
Patients who had conducted kasai procedure and suffered from postoperative cholangitis after surgery
None postoperative cholangitis
Patients who had conducted kasai procedure and followed up in a clinic,at which time they didn't present signs of cholangitis
Related Therapeutic Areas
Sponsors
Leads: Nanjing Children's Hospital

This content was sourced from clinicaltrials.gov