Accelerated Intermittent Theta Burst Stimulation for the Treatment of Non-suicidal Self-injury in Patients With Unipolar Depression and Bipolar Depression: a Sham-controlled Study
Repetitive transcranial magnetic stimulation (rTMS) has been successfully used to help patients with treatment resistant depression. However, its role in alleviating self injuries without suicidal ideation remained uncertain. This trial will compare the effectiveness of active accelerated intermittent theta burst stimulation (aiTBS) rTMS to a placebo control on non-suicidal self injury (NSSI) in patients with unipolar disorder and bipolar disorder.
• Documentation of DSM-5 criteria for current major depressive disorder (MDD) or bipolar disorder (BD) will be required for study entry.
• Ages between 12 and 18 years
• At least 1 caregivers to supervise the patient within 3 month.
• A score of greater than 17 on the HAM-D17.
• Occurrences of self injury behavior consistent with the DSM-5 criteria of NSSI more than 3 times in a month.
• Willingness to participate in the study and sign informed consents