Elucidating Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD): a Multidisciplinary Mechanistic Study
The investigators aim to examine the effect of the ketogenic diet on brain activity, metabolism, and emotions in adults with Bipolar Disorder (BD).
⁃ All participants:
• 18-40 years of age
• Not following a ketogenic diet
⁃ BD hypomanic group (n=30):
• Meeting sex proportion: 50% female
• Meeting diagnosis proportion: 50:50% Bipolar I: Bipolar II (BDI:II) (Diagnostic and Statistical Manual of Mental Disorders 5; DSM-5)
• Score greater than 10 on the Young Mania Rating Scale score(YMRS)
• BD medications will be allowed as in our previous studies: any combination of atypical antipsychotics, lithium, antidepressants, anxiolytics (common in BD)
⁃ BD euthymic group (n=30):
• Meeting sex proportion: 50% female
• Meeting diagnosis proportion: 50:50% BDI:II (DSM-5)
• Score less than or equal to 10 on YMRS
• BD medications will be allowed as in our previous studies: any combination of atypical antipsychotics, lithium, antidepressants, anxiolytics (common in BD)
⁃ Healthy Control (HC) Group (n=30):
• Sex matched with BD groups
• No psychiatric history