Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Bipolar Depression: a Double-blind, Randomized Controlled Trial
The aim of this study is to evaluate the feasibility and efficacy of deep transcranial magnetic stimulation (dTMS) as an add-on treatment for bipolar depression. Meanwhile, we aim to evaluate the effect of dTMS on cognitive function of bipolar depressive patients. we hypothesize dTMS would improve depressive symptoms and cognitive function in bipolar disorder.
⁃ Confirmed diagnosis of bipolar depression;
• Met standardized criteria for failure to achieve remission from pharmacological treatment in the current illness episode;
• Pharmacological treatment maintained unchanged for the four weeks preceding rTMS application；
• Able to read, verbalize understanding and voluntarily sign the informed consent form prior to performance of any study-specific procedures or assessments