Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study
The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS). By comparing brain activity across different groups and relating it to symptom severity, this study aims to improve our understanding of how these conditions affect the brain.
• 18 years and older
• Ability to provide written informed consent
• Adequate cognitive and language abilities to understand and complete study tasks, including clinical assessments and fNIRS procedures
• Confirmed clinical diagnosis of major depressive disorder, bipolar disorder, or mild cognitive impairment (MCI)
• Stable psychiatric or cognitive condition, without acute episodes requiring immediate intervention
• Healthy control
• o No past or current psychiatric or cognitive disorder
• Major depressive disorder (MDD):
‣ Diagnosis of major depressive disorder, confirmed through clinical evaluation.
⁃ No history of bipolar disorder or psychotic symptoms.
• Bipolar disorder:
• o Diagnosis of bipolar disorder I or II, confirmed through clinical evaluation.
• Mild Cognitive Impairment (MCI):
‣ Pre-existing clinical diagnosis of mild cognitive impairment, supported by neuropsychological testing and/or MRI, PET scan data.
⁃ No history of major psychiatric disorders, such as major depression, bipolar disorder or schizophrenia.