• Diagnosis of DSM-IV-TR of Bipolar I or Bipolar II disorder as verified by the semi-structured diagnostic interviews SCID. The diagnosis may be supported by information from significant others, and from hospital records.

• Age: 18-65 years

• Severity: meet DSM-IV-TR criteria of depressive episode and MADRS of 25 or above

• Treatment resistance: None response to two trials (during lifetime) with mood stabilizers with proven efficacy in bipolar depression (lithium, lamotrigine, quetiapine, olanzapine) and/or antidepressants.

• a A trial is defined as at least 6 weeks in adequate or tolerated dose as reported by the patient, or patients that have been unable to comply with 6 weeks trials of mood stabilizer or an antidepressant.

• b None response: Less than 50% reduction in MADRS values or still meet DSM-IV-TR criteria of depressive episode

• CRP concentration greater than 5 mg/L

• Female subjects whom are not pregnant, not breastfeeding, and not planning on becoming pregnant during the study. Female patients of childbearing potential must be using a reliable method of contraception.

• Patient competent to give informed consent according to the judgment of the clinician

• Written informed consent

• Patient sufficiently fluent in English language to ensure valid responses to psychometric testing (needed for validated neurocognitive outcomes testing)