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A Scalable Cruciferous Vegetable Intervention to Reduce Bladder Cancer Recurrence and Progression

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

This phase II trial is being done to develop and test a healthy eating program to reduce cancer recurrence (cancer that has come back after a period of improvement) and/or progression (cancer that is growing, spreading, or getting worse) in patients with non-muscle invasive bladder cancer (NMIBC). Researchers want to better understand how incorporating more cruciferous vegetables in the diet may reduce the risk of cancer recurrence or progression in men and women who were diagnosed with early-stage bladder cancer and compare whether extending the program can further improve bladder cancer outcomes. POW-R Health is a behavioral dietary intervention designed to modestly increase cruciferous vegetable (cruciferae) intake in patients. Cruciferous vegetables, such as cabbage, kale and broccoli, arugula, contain phytochemicals known as isothiocyanates (ITCs). Dietary ITCs exert potent anticancer activities against bladder cancer and can be rapidly metabolized, delivered to the bladder, and concentrated in the urine. Participating in the healthy eating program may reduce bladder cancer recurrence or progression in NMIBC survivors.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• English speaking

‣ Diagnosed with stage Tis, Ta, or T1 bladder cancer

⁃ Age 18 years old or older (no upper limit)

⁃ Resides in New York State

⁃ Cancer not reported by a lab, nursing home, or death certificate/autopsy only

⁃ Did not receive a partial or radical cystectomy

⁃ Does not have other cancer diagnosis within 12 month of bladder cancer diagnosis nor under active treatment for any other cancers

Locations
United States
New York
Roswell Park Comprehensive Cancer Center
RECRUITING
Buffalo
Contact Information
Primary
Karen Yeary, MD
askroswell@roswellpark.org
8772757724
Time Frame
Start Date: 2026-01-13
Estimated Completion Date: 2029-02-28
Participants
Target number of participants: 344
Treatments
Experimental: Adaptation
CAB members participate in maintenance phase development discussion over an hour up to 3 times per week.
Experimental: Arm II - POW-R Health Only/Core + Maintenance
Patients receive study materials and phone calls during life of study
Related Therapeutic Areas
Sponsors
Leads: Roswell Park Cancer Institute
Collaborators: National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov