Analysis of Urinary Methylation Patterns Via Liquid Biopsy as a Tool for Early Diagnosis, Non-invasive Monitoring and Prediction of Recurrence Risk in Bladder Cancer
Multicenter, observational, prospective, biological pilot study on liquid biopsy, aimed at investigating methylation profiles in relation to the early diagnosis of bladder cancer, to validate the potential of commercially available tests (e.g. BladderCARE, Bladder EpiCheck), to apply and validate tests based on targeted multi-marker or genome wide analyzes via NGS and to identify methylation profiles as a tool to infer clinical outcome.
⁃ Patient group
• age ≥ 18 years
• proven diagnosis of bladder cancer (infiltrating muscle or non-infiltrating muscle)
• performance status (PS) 0-1
• ability to follow the procedures established by the study
• written consent for participation in the study and data processing
⁃ group of healthy subjects
• age ≥ 18 years
• ability to follow the procedures established by the study
• written consent for participation in the study and data processing