Sample Collection for Ongoing Research and Product Evaluation Study - Non-muscle Invasive Bladder Cancer (SCORE-NMIBC)
The SCORE-NMIBC study is a prospective, multi-center, study designed to collect data and biological samples from participants diagnosed with non-muscle Invasive Bladder Cancer (NMIBC). Study participants will undergo research blood and urine collections, as well as tumor tissue collected as part of a standard-of-care procedure(s), for use in research. Collected samples and data will be analyzed to evaluate biomarkers associated with development and validation of cancer monitoring and detection assays (Natera cancer monitoring and detection test(s)).
• Patient is at least 18 years of age or older.
• Eastern Cooperative Oncology Group performance status ≤ 2.
• Patient has a suspected high risk non-muscle invasive bladder cancer.
• Note: The AUA/SUO risk stratification for primary non-muscle invasive bladder cancer will be used to determine high risk of tumor progression based on clinic and pathologic prognostic factors (Holzbeierlein et al., 2024):
⁃ High grade T1.
⁃ Any recurrent, High-grade TA.
⁃ High grade TA, \>3 cm (or multifocal).
⁃ BCG failure in high grade patient.
⁃ Any variant histology.\*
‣ \*e.g. Micropapillary, plasmacytoid, small cell/neuroendocrine, and sarcomatoid histologies (in pure or mixed form with associated urothelial carcinoma)
⁃ Any lymphovascular invasion.
⁃ Any high grade prostatic urethral invasion.
• Meet the following criteria:
• a. Cohort A: i. Participant has high risk ≤ T1 bladder cancer and is eligible for intravesical therapy or cystectomy. ii. Participant has been treated with intravesical and/or systemic therapy for high risk ≤ T1 bladder cancer and is entering surveillance. b. Cohort B i. Participant has high risk ≤ T1 bladder cancer and undergoing primary treatment with cystectomy. ii. Patients undergoing cystectomy following recurrence or progression of high risk ≤ T1 bladder cancer and where ≤ T1 bladder cancer is confirmed on cystectomy surgical pathology.
• Willing and able to tolerate blood draws according to Natera standard process.
• Willing to provide urine collection samples.
• Able to consent to and provide residual tumor tissue for research.
• Willing and able to comply with the study requirements.