Pilot Feasibility Study of Fecal Microbiota Transplant for the Treatment of Small Intestinal Bacterial Overgrowth
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 1
SUMMARY
The objective of the study is to assess feasibility, and clinical efficacy of a novel Fecal Microbiota Transplantation protocol for the treatment of pediatric small intestinal bacterial overgrowth (SIBO).
Eligibility
Participation Requirements
Sex: All
Minimum Age: 3
Maximum Age: 18
Healthy Volunteers: f
View:
• Patients 3-18 years old
• Patients will discontinue antibiotics for at least 1 week prior to FMT
• A diagnosis of SIBO established through lactose breath test (LBT), and showing of symptoms of SIBO
Locations
Other Locations
Canada
McMaster Children's Hospital
RECRUITING
Hamilton
Hospital for Sick Children (SickKids)
NOT_YET_RECRUITING
Toronto
Contact Information
Primary
Fariha Chowdhury, BASc, MSc, PhD(c)
chowdf1@mcmaster.ca
647-787-8297
Backup
Nikhil Pai, BSc, MD, CNSC, FRCPC, FAAP
pain@mcmaster.ca
905-521-2100
Time Frame
Start Date: 2024-03-11
Estimated Completion Date: 2026-12-31
Participants
Target number of participants: 20
Treatments
Experimental: Fecal Microbiota Transpant
Participants will receive a Fecal Microbiota transplant Infusion via participants' existing enteral feeding tubes or via elective upper endoscopy (with infusion into the duodenum). Most patients with SBS at MCH and HSC have an existing enteral feeding tube (gastrostomy or jejunostomy tube).
Related Therapeutic Areas
Sponsors
Leads: McMaster Children's Hospital
Collaborators: The Hospital for Sick Children