Characterization of Large Brain Metastases With 18F-Fluciclovine PET/CT Treated With Staged Stereotactic Radiosurgery
The spread of cancer to the brain is referred to as brain metastases. Brain metastases are a common complication of cancer. This study is being done to determine whether the use of a new imaging agent, 18F-fluciclovine, is able to detect which patients are responding to radiation therapy. In addition, this study will look at the changes of the treated brain metastases using this imaging agent over time.
• Male or female, age ≥18 years
• Performance status, Eastern Cooperative Oncology Group 0-2
• Confirmed diagnosis of brain metastases with at least one untreated lesion \>2 cm in maximum diameter
• Plan for SSRS per the treating team
• For women of childbearing potential, a negative serum pregnancy test within 14 days of registration is required
• For females of reproductive potential: use of highly effective contraception for at least 4 weeks prior to screening and agreement to use such a method during study participation and for an additional 1 week after post-treatment 18F-fluciclovine positron emission tomography/computerized tomography