Characterization of Nausea Induced by Radiation of the Dorsal Vagal Complex in the Context of Benign Brain Tumors (NausiCAA)

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Radiation
Study Type: Observational
SUMMARY

Patients irradiated to the brain frequently experience nausea. The dorsal vagal complex (DVC) area is a specific brainstem zone and has been identified as likely responsible for nausea. Existing clinical studies show correlation between dose to the DVC and nausea, but they concern tumors of the airways and upper digestive tract, where there are many confounding factors. The aim of this study is to establish a ling between radiation dose to the DVC and nausea. Defining a dose threshold to the DVC will allow radiation oncologists to optimize radiation dose distribution and reduce nausea in patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
View:

• More than 18 years old

• With benign brain tumor

• Irradiated with conventional fractionation (1,8-2Gy/fraction)

Locations
Other Locations
France
CHU de Bordeaux, Service de Radiothérapie
RECRUITING
Bordeaux
Hospices Civils de Lyon, Service d'Oncologie Radiothérapie - Hôpital Neurologique
NOT_YET_RECRUITING
Lyon
Institut de cancérologie Strasbourg Europe (ICANS), Service d'Oncologie Radiothérapie
NOT_YET_RECRUITING
Strasbourg
Contact Information
Primary
Charles DUPIN, MD, PhD
charles.dupin@chu-bordeaux.fr
:+33(0)557623310
Time Frame
Start Date: 2022-05-20
Estimated Completion Date: 2026-06
Participants
Target number of participants: 100
Treatments
Irradiated patients
Patients irradiated for benign brain tumor, without chemotherapy
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Bordeaux

This content was sourced from clinicaltrials.gov