Immunophenotype Characterization of Circulating and Tumor Infiltrating Immune Cells in Malignant Brain Tumors.
Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY
The goal of this observational study is to characterize the circulating leukocyte profile and the immune T cells distribution within the tumor in patients with malignant brain tumors and to correlate these findings with the oncological outcome. Participants will be subjected to blood sampling before surgery and for 12 months of follow-up. Additional sampling and analysis will be performed on tumor samples.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adult patients (≥18 years)
• Able to express informed consent
• With primary or secondary malignant brain tumor
• Requiring neurosurgical treatment (radiosurgery, stereotactic biopsy, surgery)
Locations
Other Locations
Italy
IRCCS San Raffaele Scientific Institute
RECRUITING
Milan
Contact Information
Primary
Laura Sincinelli
sincinelli.laura@hsr.it
0226435568
Time Frame
Start Date: 2022-08-01
Estimated Completion Date: 2029-08-01
Participants
Target number of participants: 200
Treatments
Included patients
The study population will comprise 200 (two hundred) adult patients candidate to neurosurgical treatment for newly diagnosed malignant brain tumors, able to express an informed consent.
Related Therapeutic Areas
Sponsors
Leads: Pietro Mortini, MD, Prof.