Comparison of Proton and Photon Radiotherapy of Brain Tumors: Efficiency and Side Effects in Clinical Standard Doses
This protocol compares the toxicity of radiotherapy or radiochemotherapy applied with different radiation modalities - protons or photons. Patients with different kinds of brain tumours and foreseen high-dose radiotherapy can be included. The hypothesis of the trial is that the rate of chronic toxicity 1 year after the end of radiotherapy is 15% lower after proton compared to photon treatment.
• primary brain tumor: gliomas (low or high grade), intracerebral meningiomas, pituitary adenomas, craniopharyngioma and other rare brain tumors or
• brain tumor recurrence without pre-irradiation or
• brain tumor recurrence with pre-irradiation \> 40 Gy in the overlap region with the recurrence region
• indication for radiotherapy or radiochemotherapy
• Both proton and photon therapy are possible from a medical point of view (that is no standard indication for protons or standard indication for example one-time stereotaxy
• age \>= 18 years
• general condition ECOG ≤ 2, outpatient basis possible
• indication for high dose (except group 4) radiotherapy or radiochemotherapy
• capacity to consent and present written informed consent