Evaluation of Intraoperative Contrast Enhanced Ultrasound for the Identification of Pituitary Adenoma in Cushing's Disease Compared to Other Pituitary Tumors
This pilot and feasibility study aims to combine recent advances in ultrasound imaging, specifically an endonasal transducer array and contrast enhanced ultrasound, to offer an intraoperative image-guided solution for lesion-specific surgical resection to impact clinical outcome. Should this imaging approach help isolate specific lesions and prevent surgical resection of normal pituitary tissue in this first-in-humans study, then the results will provide clinical data for a much larger multi-center clinical trial.
• Diagnosis of Cushing disease or required resection for non-corticotroph adenomas
• Agree to transsphenoidal resection.
• Patients undergoing any pituitary surgery with the study designated neurosurgeons.
• Patients whose procedures require the use of an intra-operative BK ultrasound without contrast.