Alternative Physical Activity Strategies for Breast and Prostate Cancer Survivors

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The primary aim of this study is to compare the acute glycemic effects of two novel, alternative physical activity (PA) strategies (dispersed post-meal PA, PA snacks) to a no PA condition and to exercise sessions representing the PA guidelines (standard 30-minute walking bout performed under fasting and under postprandial conditions and a standard 30-minute resistance training session) among sedentary breast cancer survivors who are currently receiving hormone therapies and age- and BMI-matched postmenopausal women without a history of cancer. The secondary aim is to determine whether the alternative PA strategies are acceptable and feasible in the free-living setting. An exploratory aim is to determine whether the outcomes differ between women with and without a history of breast cancer and use of aromatase inhibitors. The investigators hypothesize that: 1. Dispersed PA and PA snacks will result in greater reductions in 24-hour glucose and postprandial glucose compared to the no-PA baseline and similar reductions to a standard 30-minute bouts of walking; 2. The alternative PA strategies will be more feasible and have greater acceptability by cancer survivors compared to the standard 30-minute bout of walking or resistance training; and 3. The different PA strategies will have similar effects on glycemic outcomes for both breast cancer survivors and cancer-free controls. The resistance exercise session is an exploratory trial as the effects of it on acute glycemic control are understudied.

Eligibility
Participation Requirements
Sex: Female
Healthy Volunteers: t
View:

• Postmenopausal biological females diagnosed with stage I, II, or III breast cancer and currently using aromatase inhibitors (AI) for at least 3 months prior to start of study participation

• All participants must meet the following criteria:

‣ Body mass index equal to or greater than 25 kg/m\^2.

⁃ Self-report consuming three main meals daily.

⁃ Self-report as being sedentary (i.e., less than 30 minutes/week of moderate-to-vigorous aerobic physical activity and less than twice/week muscle strengthening of major muscle groups in the last three months.

Locations
Other Locations
Canada
Remote Ontario-wide
RECRUITING
Toronto
Contact Information
Primary
Amy A Kirkham, PhD
amy.kirkham@utoronto.ca
416-946-4069
Backup
Jenna B Gillen, PhD
jenna.gillen@utoronto.ca
416-978-3244
Time Frame
Start Date: 2024-10-22
Estimated Completion Date: 2026-07-01
Participants
Target number of participants: 24
Treatments
Experimental: Standard Physical Activity - Fasted
Participants will perform 30 minutes of walking at a self-selected pace 15 minutes prior to consumption of first meal in the morning (including cream/sugar/milk in coffee or tea).
Experimental: Standard Physical Activity - Post-Meal
Participants will perform 30 minutes of walking at a self-selected pace 30 minutes after the start of the first meal in the morning.
Experimental: Dispersed Physical Activity
Participants will perform 10 minutes of walking at a self-selected pace 30 minutes after the start of each main meal throughout the day (i.e., three bouts total).
Experimental: Physical Activity Snacks
Participants will perform 2 minutes of walking or marching on the spot at a self-selected pace every 30 minutes throughout the day for 7.5 waking hours.
Experimental: Muscle Strengthening
Participants will perform 30 minutes of muscle strengthening exercises targeting the major muscle groups of the whole body performed by following along with a video, to start 30 minutes after the start of the first meal in the morning.
Related Therapeutic Areas
Sponsors
Leads: University of Toronto

This content was sourced from clinicaltrials.gov