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Shoulder Denervation as Management of Post Mastectomy Irradiation Shoulder Pain: Randomized Control Trial

Status: Recruiting
Location: See location...
Intervention Type: Drug, Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Breast cancer is the second most common cancer world-wide following lung cancer. It afflicts about 1.7 million patients annually, of which 60% mandate surgery of the breast and/or the axilla, and nearly 20-50% of them may develop post mastectomy pain syndrome . After breast cancer surgery, between 6% and 86% of people may develop tight bands of fibrous tissue under their skin, known as axillary web syndrome. These bands can cause pain in the shoulder area by trying to raise or extend the arm. Shoulder pain is a common side effect of breast cancer surgery and treatment. Various medical and interventional procedures have been tried for treating postmastectomy shoulder pain, with varying efficacy . Among the interventional procedures that may have a role for treatment. Innervation of the glenohumeral joint (GHJ) can be divided into anterior and posterior innervation from articular branches of the suprascapular nerve (SN):C5 \&6 (posterior-lateral), axillary nerve (AN):C5 \&6 (anterior-lateral, inferior, and posteriorlateral), and lateral pectoral nerve (LPN): C5 \&6 (anterior superior)

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:

• Age (18-65) Years.

• ASA physical status (II- III).

• Patients with post mastectomy irradiation shoulder pain.

• Body mass index (BMI): (20-40) kg/m2.

Locations
Other Locations
Egypt
National Cancer institute
RECRUITING
Cairo
Contact Information
Primary
suzan Adlan
dr_s.adlan@hotmail.com
+201111068300
Time Frame
Start Date: 2025-08-01
Estimated Completion Date: 2026-08-01
Participants
Target number of participants: 60
Treatments
Experimental: Group 1 (Shoulder individual nerves TRF (thermal radio frequency): Patients will receive shoulder i
Thermal RF therapy will be performed under ultrasound guidance and flouroscopic guidance.
Active_comparator: Group 2 (Control): Patients will receive conservative treatment.
Patients will receive conservative treatment Acetaminophen (paracetamol) 1000 mg tid and pregabalin (lyrica)75 mg bid; can be increased, oxycodone (oxynorm) 10mg IR PRN.
Related Therapeutic Areas
Sponsors
Leads: National Cancer Institute, Egypt

This content was sourced from clinicaltrials.gov