Moderate-Intensity Exercise and Pain Sensitization in Breast Cancer Survivors: A Case-Based Study
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The aim of this study was to evaluate the feasibility, safety, and acceptability of a supervised, combined moderate-intensity aerobic and resistance training program designed to reduce pain sensitization in BCS with persistent pain. Secondary objectives included assessing changes in pain intensity, somatosensory sensitivity, and temporal summation, while tertiary objectives focused on improvements in quality of life and functional capacity.
Eligibility
Participation Requirements
Sex: Female
Healthy Volunteers: f
View:
• Adult women diagnosed with stage I-III breast cancer
• Completion of active treatment (surgery, chemotherapy, and/or radiotherapy) at least 6 months prior to enrollment
• Presence of persistent pain or altered sensation in the upper quadrant of the affected limb related to oncologic treatment
Locations
Other Locations
Spain
Universidad Rey Juan Carlos
RECRUITING
Madrid
Time Frame
Start Date: 2025-08-23
Estimated Completion Date: 2026-02-23
Participants
Target number of participants: 10
Treatments
Experimental: Moderate-Intensity Exercise
The experimental group followed a structured five-week program combining moderate-intensity aerobic and resistance training, totaling 150 minutes per week, and supervised by physiotherapists. Exercise intensity was monitored using the Borg and OMNI-Res perceived exertion scales, with prior familiarization sessions provided. Adherence was supported through attendance tracking, reminder messages, and motivational feedback. Unlike previous studies focused on fatigue or quality of life, this protocol targeted pain modulation based on neurophysiological mechanisms. Sessions included step-based aerobic routines and resistance exercises with bands, with clear safety and effort guidelines in place. No drugs or devices were used during the intervention.
No_intervention: Control Group
Participants maintained usual activities for five weeks without changing exercise habits. No additional interventions (drugs, devices, or procedures) were applied.
Related Therapeutic Areas
Sponsors
Leads: Universidad Rey Juan Carlos
Collaborators: Hospital General Universitario Gregorio Marañon