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Exploring the Feasibility of an Exercise and Noninvasive Brain Stimulation Intervention in Breast Cancer Survivors

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of this study is to assess the feasibility of a 4-week intervention combining exercise and transcranial alternating current stimulation (Ex+tACS) in breast cancer survivors who report experiencing cancer-related cognitive impairment. Feasibility will be assessed by measuring participant retention, adherence, satisfaction with the intervention, and safety. The researchers will also examine pre-to-post intervention changes in attention, executive function, working memory, perceived cognitive function, and physical function before, after, and four weeks post intervention completion in the Ex+tACS group compared to a control group who will receive exercise and a placebo tACS condition (CON).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Breast cancer survivors (≥18 years) will be eligible to participate if the following inclusion criteria is met:

• Diagnosed non-metastatic breast cancer (stages 0-3)

• Completed primary breast cancer treatment (surgery, chemotherapy, radiation) for at least 3 months

• Self-reported cognitive impairment after cancer treatment

Locations
United States
Florida
Florida Atlantic University
RECRUITING
Boca Raton
Contact Information
Primary
Ashley L Artese, PhD
aartese@fau.edu
856-534-8926
Time Frame
Start Date: 2026-01-07
Estimated Completion Date: 2027-01-01
Participants
Target number of participants: 40
Treatments
Experimental: Intervention Arm
The Exercise + transcranial alternating current stimulation (Ex+tACS) group will complete a four-week intervention consisting of 3 days/week of 30 minutes of aerobic exercise on a treadmill at a sustained moderate intensity, immediately followed by 15 min of tACS. During tACS, 6Hz alternating current stimulation will be administered to participants' prefrontal cortex (forehead region) using a tACS while the participant completes the AX Continuous Performance Test (AX-CPT).
Sham_comparator: Control
The Sham Comparator group will complete 30 minutes of aerobic exercise on the treadmill followed by the Sustained Attention-Continuous Performance Task (AX-CPT) with a sham transcranial alternating current stimulation (tACS) condition. The same procedures will be followed regarding the tACS, but stimulation will only last one minute, ramping up and down at the beginning and end of the 15-minute period, simulating the periodic tingling sensation that are reported with tACS.
Related Therapeutic Areas
Sponsors
Collaborators: Memorial Sloan Kettering Cancer Center, Florida Department of Health
Leads: Florida Atlantic University

This content was sourced from clinicaltrials.gov