Precision Prevention: Environmental Exposure Assessment in High-Risk and Early-Onset Breast Cancer Care
This study evaluates patient and provider attitudes about environmental exposure risk assessments into clinical care for female patients at average or high risk for breast cancer and/or diagnosed with early onset breast cancer.
• AIM 1 INCLUSION CRITERIA:
‣ ONE of the following:
• Either average risk of developing breast cancer (defined by woman with no Tyrer-Cuzick model ≥ 20%, no mention of Tyrer-Cuzick model, and no Pathogenic/Likely Pathogenic \[P/LP\] in breast cancer related genes) OR high risk of developing breast cancer (defined by ≥ 20% chance of developing breast cancer across lifetime measured by Tyrer-Cuzick model or gene mutation carrier, P/LP carrier in breast cancer related genes including BRCA1, BRCA2, BARD1, ATM, CHEK2, CDH1, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53) OR early onset breast cancer (defined by a breast cancer diagnosis in a patient younger than 50 years of age)
⁃ Age: ≥ 18 years
⁃ Speak English or Spanish
⁃ Sex: female
⁃ Willingness to:
• Participate in study activities
∙ Permit medical record/ clinical laboratory result review
• AIM 2 INCLUSION CRITERIA
‣ Practice at COH (i.e., genetic counselors, geneticists, oncologists, nurse practitioners)
⁃ Willingness to:
• Participate in study activities
• AIM 3 INCLUSION CRITERIA:
‣ Provide written consent
⁃ ONE of the following:
• Either average risk of developing breast cancer (defined by woman with no Tyrer-Cuzick model ≥ 20%, no mention of Tyrer-Cuzick model, and no P/LP in breast cancer related genes) OR High risk: empirical risk of developing breast cancer (defined by ≥ 20% chance of developing breast cancer across lifetime measured by Tyrer-Cuzick model and no P/LP in breast cancer related genes) OR High Risk: gene carrier (defined by P/LP carrier in breast cancer related genes, including BRCA1, BRCA2, BARD1, ATM, CHEK2, CDH1, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53)
⁃ Age: ≥ 18 years
⁃ Speak English or Spanish
⁃ Sex: female
⁃ Willingness to:
• Wear the wristband for 1 week
∙ Participate in study activities
∙ Permit medical record/ clinical laboratory result review