Breast Cancer Clinical Trials

Prospective observational study. The purpose of this project is to identify a parameter system that will allow to identify a priori the most appropriate radiotherapy technique for each patient undergoing breast radiotherapy at our center. All patients will be treated and monitored according to the local clinical practice. A total of at least 30 patients will be included in the study. Dose prescription will be 40.05 Gy (Gray) in 15 fractions. For each patient, 3 RT treatment plans will be simulated: Three-Dimensional Conformal Radiation Therapy (3D-CRT), Step-and-shoot intensity-modulated radiotherapy (IMRT S\&S), and hybrid technique (3D-CRT+IMRT). A total of 90 plans will be available. The best treatment technique will be chosen based on scoring provided by at least 3 expert clinicians. The primal plan choice will be the one with higher total rate, evaluated as a sum of 3 single rates.