The Effects of Bariatric Surgery on Kidney Oxygenation in Obese Adults With Type 2 Diabetes and Hyperfiltration
In this study the investigators will examine the effects of VAT reduction by bariatric surgery on kidney hypoxia and compare kidney oxygenation before- and after surgery in both sexes using BOLD-MRI and measures of kidney hemodynamic function. Furthermore, the investigators will assess whether kidney oxygenation is reduced in obese T2D men and women versus various controls as described below. This will determine whether kidney hypoxia can be appointed as a modifiable pathogenic factor in early DKD and non-surgical interventions targeting kidney hypoxia can be designed to slow DKD progression.
• Caucasian; man or women aged ≥18 years and \<55 years. Females must be pre-menopausal
• Type 2 diabetes mellitus or pre-diabetes with HbA1c ≥45mmol/mol and \<10% (\<94mmol/mol)
• BMI ≥35
• eGFR\>90 ml/min calculated as by CKD-EPI
• Provision of signed and dated, written informed consent prior to any study specific procedures
• Hypertension should be controlled, i.e., ≤ 155/95 mmHg.
• Scheduled for gastric bypass or gastric sleeve
• Caucasian; male of female aged ≥18 years and \<40 years. Females must be pre-menopausal
• Provision of signed and dated, written informed consent prior to any study specific procedures.
• Normal glucose tolerance confirmed by HbA1c
• No hypertension
• BMI ≥18,5 and \<25 kg/m²