Cerebral Hypoxia Clinical Trials

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Low Oxygen Therapy as a Cardiac Treatment for Improving 24-hour Blood Pressure Stability in Spinal Cord Injury

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 1/Phase 2
SUMMARY

This study examines the effects of low oxygen therapy (LOT) on the stability of 24-hour blood pressure in persons with chronic cervical spinal cord injury. This study will examine if brief episodes of breathing lower oxygen, termed low oxygen therapy (LOT), which has been shown to enhance autonomic nervous system activity, can improve blood pressure stability in individuals with spinal cord injury. The research team will assess 24-hour blood pressure, as well as cardiac, vascular, and autonomic function before and after a 4-day LOT treatment intervention. This study will advance current understanding of treatments to mitigate cardiovascular disease risk in people with spinal cord injuries.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 19
Maximum Age: 65
Healthy Volunteers: f
View:

• Are between the ages of 19-65

• Living with a chronic cervical (at or above T1) spinal cord injury of at least one year

• Are fluent in english

Locations
Other Locations
Canada
UBC Okanagan
RECRUITING
Kelowna
International Collaboration on Repair Discoveries (ICORD)
RECRUITING
Vancouver
Contact Information
Primary
Scott F Thrall, M.Sc.
sthrall@student.ubc.ca
+1 250-807-8083
Backup
Glen E Foster, Ph.D.
glen.foster@ubc.ca
+1 250-807-8224
Time Frame
Start Date: 2025-10-23
Estimated Completion Date: 2026-12
Participants
Target number of participants: 10
Treatments
Experimental: Room air control; lot oxygen therapy; recovery/washout
Participants with chronic cervical spinal cord injury will undergo a 4-day low oxygen therapy intervention.~Measurements will first be taken at least three days before the beginning of the intervention to establish baseline characteristics, immediately before and after the first day of the intervention to assess the acute response to the intervention, and on the first and fourth days after the end of the intervention to assess persistent effects and washout.
Related Therapeutic Areas
Sponsors
Leads: Glen Foster

This content was sourced from clinicaltrials.gov