Cerebral Hypoxia Clinical Trials

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Postoperative Hypoxemia Increases the Risk of Anastomotic Leak After Radical Esophagectomy

Status: Recruiting
Location: See all (6) locations...
Study Type: Observational
SUMMARY

This study aims to determine whether postoperative hypoxia (arterial partial pressure of oxygen (PaO₂)\<80 mmHg) is an independent risk factor for anastomotic leakage after esophagectomy. The investigators conducted a retrospective analysis of cases from their center over the past five years, stratifying patients into Low Pa0₂ Group and Normal Pa0₂ Group based on postoperative oxygen levels and comparing the incidence of anastomotic leakage between the groups. The goal is to establish whether hypoxia is a causative risk factor and whether correcting it can reduce the risk of anastomotic leakage.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: f
View:

• Patients diagnosed with esophageal carcinoma or benign esophageal tumors

• Patients requiring surgical resection of the lesion with subsequent esophageal reconstruction

• Patients must have had at least one postoperative arterial blood gas analysis

• Patients must have routinely undergone at least one of the following for postoperative evaluation of the anastomosis: endoscopy, CT scan, or esophagram

Locations
Other Locations
China
Sichuan Cancer Hospital
RECRUITING
Chengdu
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center
RECRUITING
Guangzhou
0817-2598459
RECRUITING
Nanchong
Shanghai Chest Hospital
RECRUITING
Shanghai
Cancer Hospital of Shantou University Medical College
RECRUITING
Shantou
The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital
RECRUITING
Shijiazhuang
Contact Information
Primary
Hong Yang, M.D.
yanghong@sysucc.org.cn
8613560405144
Backup
Yizhang Chen, M.D. candidate
chenyizhang@sysucc.org.cn
8613533718832
Time Frame
Start Date: 2021-01-01
Estimated Completion Date: 2026-12-01
Participants
Target number of participants: 2500
Treatments
Low Pa02 Group
Patients were defined as belonging to the Low PaO₂ group if they exhibited at least one recorded instance of PaO₂ \<80 mmHg within the first postoperative week.
Normal PaO2 Group
Patients maintained a PaO₂ ≥80 mmHg throughout the first postoperative week.
Related Therapeutic Areas
Sponsors
Collaborators: Hebei Medical University Fourth Hospital, Shanghai Chest Hospital, Sichuan Cancer Hospital and Research Institute, Affiliated Cancer Hospital of Shantou University Medical College, Affiliated Hospital of North Sichuan Medical College
Leads: Sun Yat-sen University

This content was sourced from clinicaltrials.gov