A Physiological Study of High PEEP During Noninvasive Ventilation in Patients With Hypoxemic Respiratory Failure
Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
To investigate the physiological effects of high positive end-expiratory pressure (PEEP) during noninvasive ventilation in patients with hypoxemic respiratory failure, and to elucidate the mechanisms underlying high PEEP-induced improvement in oxygenation.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 100
Healthy Volunteers: f
View:
• Age ≥ 18 years
• PaCO₂ ≤ 50 mmHg
• PaO₂/FiO₂ ≤ 300 mmHg
• Use of a noninvasive ventilator with esophageal pressure monitoring capability (e.g., Mindray SV70) -
Locations
Other Locations
China
The First Affiliated Hospital of Chongqing Medical University
RECRUITING
Chongqing
Contact Information
Primary
Jun Duan
duanjun412589@163.com
+86-89012680
Backup
Yiwei Min
496996728@qq.com
+8689012144
Time Frame
Start Date: 2024-03-26
Estimated Completion Date: 2026-06-30
Participants
Target number of participants: 50
Treatments
Experimental: High PEEP group
PEEP is increased stepwise from 5 cmH₂O, with increments of 5 cmH₂O every 10-20 minutes until reaching 20 cmH₂O. Once PEEP reaches or exceeds 20 cmH₂O, increments are made every 3-5 minutes until the recruitment level is achieved (i.e., stepwise increases to 5, 10, 15, 20, 25, and 30 cmH₂O). Inspiratory pressure is adjusted simultaneously to maintain a constant pressure difference.
Related Therapeutic Areas
Sponsors
Leads: Chongqing Medical University