Does the Administration of Acute Intermittent Hypoxia in Persons With Chronic Spinal Cord Injury Make Spasticity Worse?
Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury. It is hypothesized that hypoxia will decrease the reflex threshold of the biceps brachii, indicating an increase in spasticity following the AIH.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Age \>= 18
• Non-progressive spinal Cord injury at least 6 months prior
• Level of injury between C1-C8
• ISNCSCI ASIA classification C or D
• Measurable Spasticity
Locations
United States
Illinois
Shirley Ryan AbilityLab
RECRUITING
Chicago
Contact Information
Primary
William Z Rymer, MD, PhD
w-rymer@northwestern.edu
312-238-3919
Backup
Alexander Barry, MS
abarry@sralab.org
312-238-1435
Time Frame
Start Date: 2026-03-17
Estimated Completion Date: 2028-03
Participants
Target number of participants: 10
Treatments
Experimental: AIH intervention
In this Arm, participants will receive the Acute Intermittent Hypoxia Intervention. In this AIH, participants will breath alternating bouts of lowered oxygen and room air (approximately 60 seconds of each) for around 30 minutes.
Related Therapeutic Areas
Sponsors
Leads: Zev Rymer