Dose-Optimization Study of Acute Intermittent Hypoxia (DOSA-SCI): Effects on Lower-Limb Motor Function and Physiological Responsiveness in Individuals With Incomplete Spinal Cord Injury
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI). The objective is to identify the dose that most effectively improves motor output while also examining parameters that may account for variability in response.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Chronic Spinal Cord Injury (\>6 months)
• Motor incomplete SCI classified as AIS C or D
• Volitional ankle plantarflexion strength in at least one leg
Locations
United States
Illinois
Shirley Ryan AbilityLab
RECRUITING
Chicago
Contact Information
Primary
Milap Sandhu, PhD, PT
msandhu@sralab.org
312-238-6529
Time Frame
Start Date: 2026-07-27
Estimated Completion Date: 2028-07
Participants
Target number of participants: 40
Treatments
Other: Sham + AIH 15 + AIH 23
In this group, participants will undergo Sham AIH intervention first, with room oxygen, the following visit they will undergo 15, 60 second bouts of lowered oxygen, following that they will undergo 23, 60 second bouts of lowered oxygen
Other: AIH 15 + Sham + AIH 23
In this group, participants will undergo15, 60 second bouts of lowered oxygen intervention first, the following visit they will undergo sham training with room air, following that they will undergo 23, 60 second bouts of lowered oxygen
Other: AIH 23 + AIH 15 + Sham
In this group, participants will undergo 23, 60 second bouts of lowered oxygen intervention first, the following visit they will undergo 15, 60 second bouts of lowered oxygen, following that sham training with room air, following that they will undergo
Related Therapeutic Areas
Sponsors
Collaborators: Shirley Ryan AbilityLab
Leads: Milap Sandhu