Motor Training Intervention for Infants at High-Risk for Cerebral Palsy: Feasibility and Acceptability
The intervention in this study, Let's Move, is a motor intervention for infants at risk for cerebral palsy. We will test the feasibility and acceptability of the intervention as well as preliminary effectiveness.
• Age at enrollment: between 3-8 months corrected age
• Caregivers fluent in English
• Preterm infants with objectively defined severe diffuse white matter abnormality on MRI at term OR
• High-risk infants (e.g., preterm, neonatal hypoxic-ischemic encephalopathy, perinatal stroke) with moderate-severe injury on structural MRI or cranial ultrasound (e.g., basal ganglia/thalamic signal intensity, cystic periventricular leukomalacia, encephalomalacia, large stroke, and/or severe intraventricular/periventricular hemorrhage) at around term-equivalent age or before Neonatal Intensive Care Unit discharge AND either:
‣ Absent fidgety movements based on the Prechtl General Movement Assessment (GMA) between 3-4 months corrected age OR
⁃ A score of 56 or below on the Hammersmith Infant Neuromotor Examination (HINE) between 3-6 months corrected age (31)