Advancing Neurorehabilitation: Evaluating Transcutaneous Spinal Stimulation and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy
This is an intervention study to investigate the impact of spinal stimulation on mobility outcomes in children with Cerebral Palsy. Participants will complete a 16-week training program with weekly sessions of spinal stimulation and walking or activity-based training. Participants will also have the option to participate in a randomized control trial to investigate the impact of 5-Azacitidine combined with the spinal stimulation to further affect mobility outcomes.
• Diagnosis of cerebral palsy (CP) classified as Gross Motor Function Classification System (GMFCS) Levels I-V.
• Between 4 and 17 years old at the time of enrollment/consent.
• Diagnosis of spastic CP hemiplegia, diplegia, or quadriplegia.
• Stable medical condition as determined by the investigator.
• Adequate caregiver support to be able to participate in training and assessment sessions for the duration of the study, at the discretion of the Investigator.
• Capable of performing simple cued motor tasks and can follow 2-3 step commands.
• Capable of communicating an accurate yes or no answer to questions according to parent or guardian.
• Able to localize pain/ discomfort.
• Physician approval for participation.
• Parent/ guardian permission.