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Circulating HPV DNA in Cancers of the Anus and Uterine Cervix Treated With Definitive Radiation Therapy

Status: Recruiting

Location: See all (2) locations...

Intervention Type: Other, Diagnostic test, Radiation

Study Type: Observational

SUMMARY

This is a research study for individuals who have cancer associated with human papillomavirus (HPV) and are being treated with radiation as part of standard care for their cancer. Doctors leading this study will use blood tests to find out if they can detect the HPV virus in the blood of study participants before, during, and after radiation treatment. They will also collect blood and archival tumor tissue (from a previous biopsy) to perform other tests in the future that could provide more information about HPV-associated cancers and how they respond to treatment. Participation in this study will last approximately 2 years.

Eligibility

Participation Requirements

Sex: All

Minimum Age: 18

Healthy Volunteers: f

View:

• Stage I-III anal cancer or stage I-IVA cervical cancer that is p16+ based on immunohistochemistry.

• Age ≥ 18 years

• Planned to undergo radiation therapy as definitive treatment, with or without concurrent systemic therapy

Locations

United States

Illinois

University of Chicago

RECRUITING

Chicago

University of Illinois at Chicago

RECRUITING

Chicago

Contact Information

Primary

Christina Son, MD

cson@radonc.uchicago.edu

773-702-6870

Time Frame

Start Date: 2020-10-06

Estimated Completion Date: 2027-11-15

Participants

Target number of participants: 20

Treatments

Retrospective (Participants Who Have Already Been Treated for HPV-Related Cancer Before Study)

This group will use medical records from participants who have already received chemoradiation for their HPV-related anal or cervical cancer at a time before this study started. Because they have already received treatment, these participants will provide previous blood/tumor tissue samples that contain detectable HPV DNA as well as at least one post-treatment sample that their doctor collected before the study. Data from these previously collected samples will be compared to current samples from participants who are actively enrolled in this study in present day (chart review).

Prospective (Participants Who Will Receive Radiation Treatment for HPV-Related Cancer During Study)

This group is for participants who plan to receive radiation treatment (with or without chemotherapy) for their HPV-related anal or cervical cancer during the time this study will be conducted. Participants in this group will sign a consent form allowing researchers to collect their blood samples and analyze/compare them to the samples from the retrospective group of participants.

Related Therapeutic Areas

Cervical Cancer

Colonoscopy

Human Papillomavirus Infection

Endoscopy

Anal Cancer

Colorectal Cancer

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