Department of Radiation, Sun Yat-sen University
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
Evaluate the efficacy and safety of neoadjuvant chemotherapy (NAC) with albumin-bound paclitaxel and carboplatin followed by chemoradiation therapy (CRT) for stage IIIC cervical cancer patients with carcinoma \>4 cm in greatest dimension and/or lymph node \>2cm in short axis.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 70
Healthy Volunteers: f
View:
• pathologically comfirmed : squamous cell, adenocarcinoma, or adenosquamous carcinoma of the uterine cervix；
• FIGO (2018 International Federation of Gynecology and Obstetrics) stage IIIC with carcinoma \>4 cm in greatest dimension and/or lymph node \>2 cm in short axis at initial diagnosis.
• age 18 to 70 years；
• Eastern Cooperative Oncology Group performance status 0 to 2；
• adequate organ function.
Locations
Other Locations
China
Sun Yat-sen University Cancer Center
RECRUITING
Guangzhou
Contact Information
Primary
Junyun Li, M.D.
LIJUNY@sysucc.org.cn
020-87343817
Time Frame
Start Date: 2022-03-14
Estimated Completion Date: 2027-03-31
Participants
Target number of participants: 280
Treatments
Experimental: NAC plus RCT
two circles of NAC with albumin-bound paclitaxel and carboplatin followed by standard chemoradiation with weekly cisplatin plus pelvic radiation
No_intervention: RCT
standard chemoradiation with weekly cispatin plus pelvic radiation
Related Therapeutic Areas
Sponsors
Leads: Sun Yat-sen University