Cervical Cancer Brachytherapy With Interstitial Needles in 3 Fractions: Dosimetric and Clinical Outcomes

Status: Recruiting
Location: See location...
Intervention Type: Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Aim To determine the feasibility and safety of 3 fractions of high dose rate (HDR) brachytherapy with interstitial needles for cervical cancer in the outpatient setting Primary objective To determine the clinical outcome (2-yr local control rate, loco-regional control rate, progression free survival and overall survival) Secondary objective To determine the long-term toxicities of this regimen based on CTCAE v5

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 21
Healthy Volunteers: f
View:

• 21 years old and above

• Histologically proven squamous cell carcinoma, adenocarcinoma, adenosquamous or poorly differentiated cervical cancer

• Clinically or radiologically stage IB - IVA cervical cancer based on TNM 8th Edition

• ECOG performance status 0, 1, or 2

• To complete external beam radiotherapy and brachytherapy in NUH

• Written, voluntary informed consent

• Patients must be accessible for follow up and management in NUH

Locations
Other Locations
Singapore
National University Hospital
RECRUITING
Singapore
Contact Information
Primary
Fatin Aliyah, BSc
fatin_hussin@nuhs.edu.sg
+6581005851
Time Frame
Start Date: 2023-06-26
Estimated Completion Date: 2026-12
Participants
Target number of participants: 56
Treatments
Experimental: 3 fractions
Related Therapeutic Areas
Cervical Cancer
Sponsors
Leads: National University Hospital, Singapore

This content was sourced from clinicaltrials.gov

Similar Clinical Trials

Phase II, Single-Arm, Multicenter Clinical Study of Iparomlimab and Tuvonralimab in Combination With Paclitaxel Plus Cisplatin/Carboplatin and Radiotherapy for the Treatment of Locally Recurrent and Oligometastatic Cervical Cancer

Phase II, Single-Arm, Multicenter Clinical Study of Iparomlimab and Tuvonralimab in Combination With Paclitaxel Plus Cisplatin/Carboplatin and Radiotherapy for the Treatment of Locally Recurrent and Oligometastatic Cervical Cancer

Enrollment Status: Recruiting
Publish Date: April 24, 2025
Intervention Type: Drug, Radiation
Study Phase: Phase 2

A Prospective Randomized Controlled Trials of Neoadjuvant Chemotherapy Combined With Serplulimab Followed by Concurrent Chemoradiation Versus Concurrent Chemoradiation Therapy Alone in Advanced Cervical Cancer

A Prospective Randomized Controlled Trials of Neoadjuvant Chemotherapy Combined With Serplulimab Followed by Concurrent Chemoradiation Versus Concurrent Chemoradiation Therapy Alone in Advanced Cervical Cancer

Who is this study for: Patients with advanced cervical cancer
Enrollment Status: Recruiting
Publish Date: December 27, 2023
Intervention Type: Radiation, Drug
Study Drug: NACT
Study Phase: Phase 3

A Feasibility Study of E7 TCR-T Cell Induction Therapy for Locoregionally Advanced HPV-Associated Cancers

A Feasibility Study of E7 TCR-T Cell Induction Therapy for Locoregionally Advanced HPV-Associated Cancers

Enrollment Status: Recruiting
Publish Date: August 19, 2025
Intervention Type: Drug, Biological
Study Phase: Phase 1/Phase 2
View All