Online Adaptive Radiotherapy (oART) in Radical Radiotherapy for Cervical Cancer - a Multi-center Randomized Controlled Study
This study aims to evaluate the clinical efficacy and safety of online adaptive radiotherapy for cervical cancer patients received radical radiotherapy. By comparing with image-guided radiotherapy, the study explores the potential advantages of online adaptive radiotherapy in reducing treatment toxicity and improving local control.
• 18-70 years old;
• Pathologically confirmed diagnosis of cervical cancer and pathological type of cervical squamous carcinoma;
• 2018 FIGO Stage Ib3, II, and IIIC1
• Proposed radical pelvic radiotherapy + concurrent sensitizing chemotherapy (platinum-based (cisplatin 30-40mg/m2 or carboplatin alone), starting concurrently in the first week, ≥5 courses)
• ECOG score 0-2
• Life expectancy greater than 6 months
• Ability to remain lying down for more than 30 minutes
• Patients were fully voluntary and autonomous and co-operated in signing the study informed consent form
• Complete blood count and basal metabolic indexes within 14 days before enrolment must meet the following requirements: NEUT ≥ 1.5\*109/L, HGB ≥ 60g/L, platelets ≥ 100×109/, blood creatinine \<1.5 mg/dL. AST and ALT are within 2 times the upper limit of normal
⁃ Must complete baseline assessments and investigations required before treatment before enrolment
⁃ be eligible for regular follow-up