Understanding the Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy
Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Observational
SUMMARY
The goal of this observational study is to learn more about the biology of cervical cancer in women who receive radiation therapy for this condition. The main question it aims to answer is: Does radiation therapy alter the expression of tissue factor and other molecules in cervical cancer over time? Participants already scheduled for radiation therapy for cervical cancer as part of their regular medical care will provide blood and biopsies of cervical cancer or of the upper portion of the vagina before, during, and on the last day of radiation therapy.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Healthy Volunteers: f
View:
• Age 18 years or older
• Pathological diagnosis of cervical cancer
• Scheduled to receive brachytherapy for cervical cancer
Locations
United States
California
University of California San Diego
RECRUITING
La Jolla
Contact Information
Primary
Jyoti Mayadev, MD
CancerCTO@health.ucsd.edu
858-822-5354
Backup
Erika Peterson
CancerCTO@health.ucsd.edu
858-822-5354
Time Frame
Start Date: 2025-08-04
Estimated Completion Date: 2027-08
Participants
Target number of participants: 20
Treatments
Cervical cancer biopsy
Using tumor biopsies collected before, during, and after radiotherapy, the investigators will:~1. Evaluate if irradiation alters tissue factor expression in tumors.~2. Determine the temporal changes of biomarkers in the irradiated tumor immune microenvironment.
Vaginal apex biopsy
Using vaginal tissue biopsies collected before, during, and after radiotherapy, the investigators will:~1. Evaluate if irradiation alters biomarkers of fibrosis in the vaginal tissue.~2. Determine the temporal changes of inflammatory biomarkers that increases the stenosis molecular cascade in the irradiated tumor immune microenvironment.
Related Therapeutic Areas
Sponsors
Leads: University of California, San Diego