⁃ Patients will be ≥45 years of age and meet one of the following criteria:

• Abnormal uterine bleeding

• Postmenopausal bleeding

⁃ OR

⁃ Patients ages 18 - 44 years of age and meet these criteria

• Abnormal uterine bleeding

• One risk factor for endometrial cancer (BMI ≥30 or PCOS or Tamoxifen use)

⁃ Patients will be ≥18 years of age and meet at least one of the following criteria:

• Presence of biopsy-proven EC (any histology, including uterine carcinosarcoma) and surgical intervention planned. Surgical intervention can include any of the following: hysterectomy, D\&C, hysteroscopic resection

• Biopsy showing AEH or EIN with surgical intervention planned. Surgical intervention can include any of the following: hysterectomy, D\&C, hysteroscopic resection, etc)

⁃ Patients will be ≥18 years of age, have a cervix and meet at least one of the following criteria:

• History of current abnormal cervical/endocervical Pap test for which the patient is presenting for colposcopy

• Cervical mass identified on physical exam and patient referred for cervical biopsy, even if colposcopy not recommended or indicated

• Planned clinically indicated surgical excisional biopsy or removal of the cervix (cold knife cone, LEEP, hysterectomy) for abnormal Pap test, cervical dysplasia, cervical mass, or biopsy-proven invasive cervical cancer (adenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma, or less common primary cervical carcinomas all eligible)

⁃ Patients will be ≥45 years of age and should meet at least one of the following criteria:

• Undergoing hysterectomy with biopsy-proven or clinically presumed (based on imaging and/or clinical symptoms) benign gynecologic or uterine pathology of fibroids, endometriosis, adenomyosis, or benign endometrial polyps.

• Undergoing any gynecologic surgery in which a benign pathologic tissue diagnosis of fibroids, endometriosis, adenomyosis, or benign endometrial polyp is anticipated to be confirmed.

⁃ Patients with a uterus will be ≥45 years of age and should meet the following criteria:

• Presenting for GYN wellness exam, ± Pap test

• No change in medical conditions, new diagnoses, or new medications within the past 6 months

⁃ Patients ≥50 years of age and:

• Postmenopausal

• At least 1 intact ovary

• Diagnosis of an adnexal mass or a clinical suspicion of early-stage ovarian cancer (including fallopian tube cancer)

• Planned surgery for the adnexal mass

• For vaginal fluid collection, patient must have a uterus, cervix and at least 1 intact fallopian tube\* (without prior tubal ligation/occlusion)

⁃ Women will be ≥18 years of age and meet the following criteria:

• Presence of clinically probable ovarian, fallopian tube, or primary peritoneal cancer (all under the umbrella of OC) based on clinical findings of any/all of the following: imaging showing adnexal and/or abdominal masses consistent with probable ovarian cancer, omental caking, elevated CA125, ascites, imaging-guided biopsy consistent with OC pathology

• Newly diagnosed with ovarian, fallopian tube or primary peritoneal cancer without neoadjuvant therapy

• At least one intact ovary

• For vaginal fluid collection, patient must have a uterus, cervix and at least 1 intact fallopian tube\* (without prior tubal ligation/occlusion)