Epidemiological Factors and Optimization of Conservative Approaches to Precancerous Lesions of Female Reproductive Organs
Status: Recruiting
Study Type: Observational
SUMMARY
Objectives: * Evaluate spontaneous regression/progression over two years based on HPV HR genotyping (three groups - according to Alinity: high, intermediate, and low risk). * Assess spontaneous regression/progression over two years based on HPV HR genotyping and viral load in HPV-vaccinated vs. non-vaccinated patients. * Evaluate spontaneous regression/progression over two years based on methylation results. * Assess spontaneous regression/progression over two years based on CinTec plus results.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 46
Healthy Volunteers: f
View:
• Informed Consent
• cervical biopsy - HG lesion
• Age: 18-46 years
• colposcopicaly visible transformation zone
• HPV: Unvaccinated
• cytology all except AIS, adenocarcinoma, squamous cell carcinoma, AGC NEO
Contact Information
Primary
Lukas Rob, Prof. MUDr., Csc.
lukas.rob@fnkv.cz
+420 296472368
Time Frame
Start Date: 2024-11-01
Estimated Completion Date: 2029-12
Participants
Target number of participants: 200
Treatments
Unvaccinated
Without adjuvant vaccination for HPV
Vaccinated
Adjuvantly vaccinated against HPV with Gardasil-9
Related Therapeutic Areas
Sponsors
Leads: Nikola Janovska