Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
Who is this study for? Patients with Chalazion
What treatments are being studied? Incision and Curettage
Status: Recruiting
Location: See location...
Intervention Type: Drug, Procedure
Study Type: Interventional
Study Phase: Phase 3
SUMMARY
Local injection of 5-fluorouracil into a chalazion (stye) is as effective as local injection of triamcinolone (steroid) and incision and curettage for treatment of chalazia.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Single or multiple chalazia in a single eyelid
Locations
United States
Washington
University of Washington Eye Institute at Harborview
RECRUITING
Seattle
Contact Information
Primary
Simona Vuletic
simona@uw.edu
206-520-9728
Backup
Ian Luttrell
lutri@uw.edu
206-520-8305
Time Frame
Start Date: 2013-12
Estimated Completion Date: 2026-07
Participants
Target number of participants: 120
Treatments
Active_comparator: Incision and Curettage
A vertical incision over the area of chalazion will be done. Inflammatory material will be removed and the chalazion capsule will be excised.
Active_comparator: Injection of Triamcinolone Acetonide
0.1 ml of triamcinolone is injected directly in the chalazion.
Active_comparator: Injection of 5-fluorouracil
0.1 ml of 5-fluorouracil is injected directly in the lesion transconjunctivally.
Active_comparator: Injection of triamcinolone/5FU mixture
0.1 ml of a 4:1 mixture of 4 parts 5-FU and 1 part triamcinolone is injected in the lesion.
Authors
Shu-Hong Chang
Related Therapeutic Areas
Sponsors
Leads: University of Washington