• Radiologically strong suspicion of pCCA

• Tumor can involve intrahepatic portal vein without thrombosis of extrahepatic portal vein

• Tumor can involve hepatic artery distal to gastroduodenal artery or involve replaced hepatic artery

• First time pCCA

• Disease deemed not eligible for liver resection based on tumor location or underlying liver dysfunction

• No extrahepatic disease, or lymph node involvement detected on imaging

• No signs of extrahepatic metastatic disease according to PET-CT scan

• No signs of extrahepatic metastatic disease according to CT or MR (chest/abdomen/pelvis) scan within 4 weeks prior to the faculty meeting at the transplant unit

• At least 18 years of age

• Good performance status, Eastern Cooperative Oncology Group (ECOG) score: 0 or 1

• Satisfactory blood tests Hb \>10g/dl, neutrophiles \>1.0 (after any G-CSF), TRC \>50, Bilirubin\<3 x upper normal level, ASAT, ALAT\<5 x upper normal level, Creatinine \<1.5 x upper normal level. Albumin above lower normal level, Normal IgG4 levels

• Signed informed consent and expected cooperation of the patients for the treatment and follow up must be obtained and documented according to GCP, and national/local regulations

• Received chemotherapy for at least 6 months with at least 10% response according ti RECIST criteria and with no progression of disease at time of Lt

• At least 10 months from diagnosis

• Patient must be accepted for transplantation before progressive disease

• Twelve months or more time span from the diagnosis of pCCA and date of being listed for liver transplantation